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VENTILATOR
ASSOCIATED
PNEUMONIA

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 Our first live biotherapeutics product is for the treatment of Ventilator-associated pneumonia (VAP), a type of pneumonia that develops 48–72 hours following endotracheal intubation of patients required assisted ventilation [1-3].
 

  • Around 400,000 VAP cases/year in Europe and USA VAP mortality 3 - 17%

  • Increases intensive care unit (ICU) stay between 4 and 13 days
     

  • Incremental hospitalization costs of 25,000$ - 40,000$ per  diagnosis (USA)
     

  • 50% of all antibiotics administered in ICUs are for treatment  of VAP
     

  • Significant resistance to antibiotics: 8.3% vancomycin, 50% methilin, rising for piperacillin-tazobactam (PTZ), amikacin and imipenem (IPM)

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Our innovative solution

 Our VAP product uses attenuated lung bacteria to deliver therapeutic agents with antibacterial activity in the lung in a controlled, local and continuous manner.
This product has already demonstrated activity in vitro and in animal models.

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 [1] Chastre, Ventilator-associated pneumonia. Am J Respir Crit Care Med, 2002.
[2] Kalanuria, Ventilator-associated pneumonia in the ICU. Crit Care, 2014.
[3] Fernandez-Barat, Biofilms in ventilator-associated pneumonia. Future Microbiol, 2016

 References

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