Our first live biotherapeutics product is for the treatment of Ventilator-associated pneumonia (VAP), a type of pneumonia that develops 48–72 hours following endotracheal intubation of patients required assisted ventilation [1-3].
Around 400,000 VAP cases/year in Europe and USA VAP mortality 3 - 17%
Increases intensive care unit (ICU) stay between 4 and 13 days
Incremental hospitalization costs of 25,000$ - 40,000$ per diagnosis (USA)
50% of all antibiotics administered in ICUs are for treatment of VAP
Significant resistance to antibiotics: 8.3% vancomycin, 50% methilin, rising for piperacillin-tazobactam (PTZ), amikacin and imipenem (IPM)
Our innovative solution
Our VAP product uses attenuated lung bacteria to deliver therapeutic agents with antibacterial activity in the lung in a controlled, local and continuous manner.
This product has already demonstrated activity in vitro and in animal models.
 Chastre, Ventilator-associated pneumonia. Am J Respir Crit Care Med, 2002.
 Kalanuria, Ventilator-associated pneumonia in the ICU. Crit Care, 2014.
 Fernandez-Barat, Biofilms in ventilator-associated pneumonia. Future Microbiol, 2016