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Our Platform

Two different lung-specific bacterial chassis (MycoChassis and LactoChassis), designed to treat acute and chronic respiratory diseases, respectively. These chassis are able to expose antigens or deliver therapeutic agents in the lung in a controlled, local and continuous manner.

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IMMUNE SYSTEM MODULATION

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Lung Cancer

Immune stimulatory interleukins, nanobodies against immune check point inhibitors

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Asthma

Modified interleukins

nanobodies

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Pulmonary alveolar proteinosis

GM-CSF mutants

ANTIMICROBIAL AND BIOFILM DISPERSION

ACUTE

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Cystic Fibrosis

Infectious diseases

Antibacterial and

biofilm-dispersing agents

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VAP

Infectious diseases

Antibacterial and

biofilm-dispersing agents

PROTEIN SUPPLEMENTATION

FOR GENETIC DISEASES

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Chronic obstructive

Pulmonary disease

A1AT

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Interstitial lung disease

Surfactant proteins

Publications by scientific team

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Bacterial expression of a designed single-chain IL-10 prevents severe lung inflammation.

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SURE editing: combining oligo-recombineering and programmable insertion/deletion of selection markers to efficiently edit the Mycoplasma pneumoniae genome.

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MycoWiki: Functional annotation of the minimal model organism Mycoplasma pneumoniae.

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Functional Characterization of the Cell Division Gene Cluster of the Wall-less Bacterium Mycoplasma genitalium.

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Widespread ribosome stalling in a genome-reduced bacterium and the need for translational quality control.

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LoxTnSeq: random transposon insertions combined with cre/lox recombination and counterselection to generate large random genome reductions.

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An engineered Mycoplasma pneumoniae to fight Staphylococcus aureus.

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Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo

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Lox'd in translation: contradictions in the nomenclature surrounding common lox-site mutants and their implications in experiments

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A RAGE Based Strategy for the Genome Engineering of the Human Respiratory Pathogen Mycoplasma pneumoniae

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Mycoplasma pneumoniae Genome Editing Based on Oligo Recombineering and Cas9-Mediated Counterselection

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CReasPy-Cloning: A Method for Simultaneous Cloning and Engineering of Megabase-Sized Genomes in Yeast Using the CRISPR-Cas9 System

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SynMyco transposon: engineering transposon vectors for efficient transformation of minimal genomes

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